Alleviate excessive stress that exceeds the body's natural regulatory functions

身体の自然な調節機能を超える過剰なストレスを軽減しましょう。


[EN]

 The hormone GDF15 and its receptor GFRAL function as a physiological feedback mechanism that limits alcohol intake.

 GDF15 is an indicator that rises slowly in response to sustained exposure and cellular stress.

 In alcohol-dependent patients, drinking continues despite high GDF15 levels. This may be because motivation outweighs inhibitory signals, or because the receptor system's sensitivity is reduced (resistance).


 In other words, it is important to alleviate excessive stress that exceeds the body's natural regulatory functions.

 I recommend using the music I've created as one way to effectively alleviate everyday stress without any side effects.


[JP]

　ホルモンGDF15とその受容体GFRALは、アルコール摂取量を制限する生理的フィードバック機構として機能しています。

　GDF15は、持続的な曝露や細胞ストレスに応じて緩やかに上昇する指標です。

　アルコール依存症患者では、GDF15が高いにもかかわらず飲酒が続きますが、これは抑制シグナルを上回る動機付けが発生しているためか、あるいは受容体系の感受性が低下（抵抗性）している可能性があります。


　つまり、生来の制御機能を上回るような過度のストレスを緩和することが重要になります。

　日常のストレスを適切に緩和できる、副作用のない方法の一つとして、私の制作した音楽を活用することをお勧めします。

A loss-of-function variant in GFRAL associates with increased alcohol consumption in humans

Alcohol is an ancient and enduring component of the human diet, yet it is a dose-dependent cytotoxin and teratogen, raising the possibility that endogenous, state-dependent mechanisms constrain intake. Growth differentiation factor 15 (GDF15) is an endocrine hormone that rises during pregnancy—predominantly via secretion from blastocyst-derived placental trophoblasts into the maternal circulation—and is also induced in other tissues, particularly hepatocytes, by toxins and cellular stress. However, its function in humans remains unclear. Here, we show that circulating GDF15 levels are elevated 5-fold in individuals with alcohol dependence, identify a rare loss-of-function variant in the GDF15 receptor gene GFRAL associated with approximately 2.6 additional UK alcohol units (∼21 g ethanol) per week, and demonstrate that recombinant GDF15 reduces alcohol drinking in mice. Collectively, these findings support a model in which GDF15 acts as an endocrine signal induced by chronic alcohol ex

bioRxiv

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